Journal of Occupational Medicine and Toxicology

Table 1 The correlation between IFN-γ and IL-12p70 released by human PBMC.

From: The role of interleukin-12 in the heavy metal-elicited immunomodulation: relevance of various evaluation methods

	*Cadmium acetate*				*Mercuric chloride*
	mAb-stimulation		hkSE-stimulation		mAb-stimulation		hkSE-stimulation
Donor	r	p	r	p	r	p	r	p
1	0.84	0.0006	0.41	0.1826	0.85	<0.0001	0.72	0.0024
2	0.83	0.001	0.51	0.0893	0.96	<0.0001	0.73	0.0022
3	0.95	<0.0001	0.06	0.8629	0.94	<0.0001	0.80	0.0004
4	0.83	0.001	0.70	0.0114	0.89	<0.0001	0.70	0.0034
5	0.90	<0.0001	0.86	0.0003	0.27	0.3278	0.87	<0.0001
6	0.90	<0.0001	0.72	0.0082	0.96	<0.0001	0.85	<0.0001
7	0.64	0.0261	0.50	0.1006	0.91	<0.0001	0.44	0.0983
8	0.90	<0.0001	0.87	0.0003	0.63	0.0121	0.86	<0.0001
9	0.93	<0.0001	0.76	0.0045	0.16	0.5499	0.26	0.3549
10	0.63	0.0283	0.83	0.001	0.84	<0.0001	0.90	<0.0001
11	0.97	<0.0001			0.23	0.4201
12	0.94	<0.0001			0.78	0.0007
13	0.80	0.0016
14	0.94	<0.0001
Mean	1	<0.0001	0.59	0.0415	0.93	<0.0001	0.71	0.0032

Human peripheral blood mononuclear cells (PBMC) were cultured for 24 hr in absence or presence of cadmium acetate or mercuric chloride and stimulated either by monoclonal antibodies (mAb: anti-CD3/anti-CD28/anti-CD40) or heat-killed Salmonella enterica serovar Enteritidis (hkSE). Cytokine values were evaluated in cell supernatants using ELISA; r represents Spearman correlation values estimated for each sample. The last raw represents the Spearman correlation between the mean values of IFN-γ and IL-12p70 of all investigated donors.

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ISSN: 1745-6673

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